concept

CGAS-STING PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CGAS-STING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

279Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CGAS-STING PATHWAY
Key Genes/Proteins	CGAS, CXCL10
Related Diseases	ALS, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, ASTROCYTE REACTIVITY

Pathway Diagram

graph TD
    CGAS_STING_PATHWAY["CGAS-STING PATHWAY"]
    style CGAS_STING_PATHWAY fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CGAS_STING_PATHWAY -->|"activates"| innate_immune_response["innate immune response"]
    CGAS_STING_PATHWAY -->|"involved_in"| Innate_Immunity["Innate Immunity"]
    CGAS_STING_PATHWAY -->|"promotes"| astrocyte_senescence["astrocyte senescence"]
    CGAS_STING_PATHWAY -->|"causes"| cardiac_inflammation(cardiac inflammation)
    CGAS_STING_PATHWAY -->|"causes"| ageing_related_inflammation(ageing-related inflammation)
    CGAS_STING_PATHWAY -->|"upregulates"| PRO_INFLAMMATORY_CYTOKINES([PRO-INFLAMMATORY CYTOKINES])
    CGAS_STING_PATHWAY -.->|"inhibits"| MTOR([MTOR])
    CGAS_STING_PATHWAY -->|"promotes"| neurodegeneration["neurodegeneration"]
    CGAS_STING_PATHWAY -->|"mediates"| Proinflammatory_Response["Proinflammatory Response"]
    CGAS_STING_PATHWAY -->|"activates"| Sterile_Inflammation["Sterile Inflammation"]
    Dna["Dna"] -->|"activates"| CGAS_STING_PATHWAY
    Mitophagy["Mitophagy"] -->|"interacts"| CGAS_STING_PATHWAY
    Substance_P([Substance P]) -.->|"inhibits"| CGAS_STING_PATHWAY
    Mitochondrial_DNA["Mitochondrial DNA"] -->|"activates"| CGAS_STING_PATHWAY
    substance_P([substance P]) -.->|"inhibits"| CGAS_STING_PATHWAY
    pathogenic_DNA([pathogenic DNA]) -->|"activates"| CGAS_STING_PATHWAY
    PINK1([PINK1]) -.->|"inhibits"| CGAS_STING_PATHWAY
    mitochondrial_DNA([mitochondrial DNA]) -->|"activates"| CGAS_STING_PATHWAY
    Damaged_Mitochondria(Damaged Mitochondria) -->|"activates"| CGAS_STING_PATHWAY
    Damaged_mitochondria["Damaged mitochondria"] -->|"activates"| CGAS_STING_PATHWAY

Outgoing (136)

Target	Relation	Type	Str
neurodegeneration	implicated_in	process	1.00
innate immune response	activates	pathway	0.95
Amyotrophic Lateral Sclerosis	associated_with	disease	0.95
Neuroinflammation	promotes	process	0.95
Neurodegeneration	promotes	process	0.95
Innate Immunity	involved_in	process	0.95
astrocyte senescence	promotes	process	0.92
NLRP3 Inflammasome Activation	activates	process	0.90
Pathogen Clearance	promotes	process	0.90
Proinflammatory Response	mediates	process	0.90
neuroinflammation	mediates	process	0.90
Traumatic Brain Injury	involved_in	disease	0.90
Mitochondrial DNA	associated_with	biomarker	0.90
neurodegeneration	promotes	process	0.90
Neurodegenerative Diseases	implicated_in	disease	0.90
PD-L1	upregulates	protein	0.90
tumor-derived DNA	regulates	phenotype	0.90
neuroinflammation	regulates	process	0.90
PRO-INFLAMMATORY CYTOKINES	upregulates	protein	0.90
MTOR	inhibits	protein	0.90
Neuroinflammation	contributes_to	process	0.90
Neurodegeneration	contributes_to	process	0.90
Parkinson's Disease	contributes_to	disease	0.90
cardiac inflammation	causes	phenotype	0.90
ageing-related inflammation	causes	phenotype	0.90
Sterile Inflammation	activates	process	0.90
Autophagy	activates	process	0.90
Neuroinflammation	mediates	process	0.90
aging	associated_with	process	0.85
PRO-INFLAMMATORY CYTOKINES	upregulates	protein	0.85
Inflammatory Cytokine Expression	upregulates	process	0.85
Parkinson'S Disease	contributes_to	disease	0.85
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.85
Neurodegenerative disorders	associated_with	disease	0.85
Inflammatory Cytokine Expression	upregulates	process	0.85
Abnormal Glial Activation	involved_in	process	0.85
senescence	regulates	process	0.85
Dopaminergic neuronal loss	mediates	phenotype	0.85
Low-Grade Inflammation	activates	process	0.85
Ataxia-Telangiectasia	contributes_to	disease	0.85
Ferroptosis	regulates	process	0.85
cellular senescence	promotes	process	0.85
NLRP3 inflammasome activation	regulates	process	0.85
systemic inflammation	promotes	phenotype	0.85
Aging	involved_in	phenotype	0.85
pulmonary fibrosis	promotes	disease	0.85
innate immune activation	activates	process	0.85
Cellular Senescence	involved_in	process	0.85
Proinflammatory Response	activates	process	0.85
neuroinflammation	causes	phenotype	0.85

Incoming (143)

Source	Relation	Type	Str
Mitophagy	interacts_with	process	0.95
Dna	activates	compound	0.95
PGAM5	activates	protein	0.95
mtDNA efflux	activates	process	0.95
Cytosolic DNA buildup	activates	process	0.95
Substance P	inhibits	protein	0.93
Mitochondrial DNA	activates	compound	0.92
STING	part_of	gene	0.90
mitochondrial DNA release	activates	process	0.90
RU.521	inhibits	drug	0.90
OMA1	activates	protein	0.90
Damaged mitochondria	activates	organelle	0.90
mitochondrial DNA	activates	protein	0.90
substance P	inhibits	protein	0.90
pathogenic DNA	activates	gene	0.90
PINK1	inhibits	gene	0.90
Damaged Mitochondria	activates	phenotype	0.90
Mitochondrial Dna	activates	biomarker	0.90
TDP-43 pathology	associated_with	mechanism	0.90
IL-6-STAT3 PATHWAY	regulates	pathway	0.88
Mitophagy	inhibits	process	0.85
STING	involved_in	protein	0.85
H-151	inhibits	drug	0.85
Nuclear Dna	activates	biomarker	0.85
Protein Phase Separation	activates	mechanism	0.85
mtDNA	activates	biomarker	0.85
Mitochondrial dysfunction	activates	mechanism	0.85
BCL-2-Mediated Apoptotic Machinery	activates	process	0.85
Disturbed intracellular trafficking	activates	process	0.85
Mitochondrial DNA Release	activates	process	0.85
Impaired DNA repair	activates	mechanism	0.80
α-Synuclein aggregation	activates	mechanism	0.80
Effective Mitophagy	inhibits	process	0.80
FGF21	inhibits	protein	0.80
tumor-derived DNA	activates	gene	0.80
Cellular Stress Response	activates	process	0.75
APOPTOSIS	triggers	process	0.70
TSG	inhibits	drug	0.70
CANCER	activates	disease	0.70
ISCHEMIA	regulates	disease	0.70
ISCHEMIA	activates	disease	0.70
DNA double-strand breaks	activates	process	0.70
mitophagy	inhibits	process	0.70
damaged mitochondria	activates	cell_type	0.70
microglia	expresses_in	cell_type	0.70
APOE3S/S	inhibits	gene	0.70
BCL2	activates	protein	0.70
dysfunctional mitophagy	activates	process	0.70
VPS13C	regulates	protein	0.70
ASTROCYTE	exacerbates	cell_type	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity